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Endoplasmic Reticulum-Mitochondria Contacts are apical hotspots of lipid peroxidation driving ferroptosis

2024-05-03

Abstract excerpt

<title>Abstract</title> <p>Peroxidation of membrane phospholipids (PLs) is a hallmark of ferroptosis. ER and mitochondria have been implicated in ferroptosis, but whether intracellular PL-peroxidation ensues at their contact sites (EMCSs) is unknown. Using super-resolution live imaging we charted the immediate spatiotemporal events triggered by ferroptosis at the inter-organelle level. EMCSs expand minutes after...

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Literature Corpus work
e0e36c13-5a4e-5ace-a17b-761e02a9d077
DOI
10.21203/rs.3.rs-4311835/v1
Open publication

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