Article

Unveiling the guardians: IL-26-expressing MAIT cells protect epithelial barrier function and are dysregulated in Crohn’s disease

2024-06-03

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND & AIMS</h4> Inflammatory bowel disease (IBD) is characterized by a dysregulated immune response against the host’s microbiome. Mucosal-associated invariant T (MAIT) cells recognize microbiota-derived riboflavin metabolites and play a crucial role in mucosal homeostasis. However, their specific role in IBD remains enigmatic. MAIT cells express IL-26, a novel IL-10 family cytokine...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7e8565ac-369f-5557-bcc0-92a97ebf9a2e
DOI: 10.1101/2024.06.02.597015

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Unveiling the guardians: IL-26-expressing MAIT cells protect epithelial barrier function and are dysregulated in Crohn’s diseaseDOI 10.1101/2024.06.02.597015Read

Pro-inflammatory innate-like T cells are expanded in the blood and inflamed intestine in Crohn’s DiseaseSemantic proximity Read

Colonic mucosal associated invariant T cells in Crohn’s disease have a diverse and non-public T cell receptor beta chain repertoireSemantic proximity Read

Insights into Modeling Inflammatory Bowel Disease from Stem Cell Derived Intestinal OrganoidsSemantic proximity Read

Integration of single-cell transcriptome and genetic profiles reveals critical cell types and genes in inflammatory bowel diseaseSemantic proximity Read

T cell mediated impairment of epithelial integrity in Crohn’s diseaseSemantic proximity Read

A collection of patient-derived intestinal organoid lines reveals epithelial pheno-types associated with genetic drivers of pediatric inflammatory bowel diseaseSemantic proximity Read

Dictionary of human intestinal organoid responses to secreted niche factors at single cell resolutionSemantic proximity Read

Epithelia mediate inflammation with myeloid cells in Crohn’s disease patients under treatmentSemantic proximity Read

A Specialized Epithelial Cell Type Regulating Mucosal Immunity and Driving Human Crohn’s DiseaseSemantic proximity Read

Celiac disease patient derived iPSC–small intestinal epithelial cells are more persistent under cytokine stimuli than healthy control cellsSemantic proximity Read

Modeling Inflammatory Bowel Disease by Intestinal OrganoidsSemantic proximity Read

Single-Cell RNA Sequencing of Terminal Ileal Biopsies Identifies Signatures of Crohn’s Disease PathogenesisSemantic proximity Read