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A Specialized Epithelial Cell Type Regulating Mucosal Immunity and Driving Human Crohn’s Disease

2023-10-02

Abstract excerpt

<h4>ABSTRACT</h4> Crohn’s disease (CD) is a complex chronic inflammatory disorder that may affect any part of gastrointestinal tract with extra-intestinal manifestations and associated immune dysregulation. To characterize heterogeneity in CD, we profiled single-cell transcriptomics of 170 samples from 65 CD patients and 18 non-inflammatory bowel disease (IBD) controls in both the terminal ileum (TI) and ascendin...

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Literature Corpus work
b63c1fa7-3161-5fba-bc0a-84dbe122d364
DOI
10.1101/2023.09.30.560293
Open publication

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