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T cell mediated impairment of epithelial integrity in Crohn’s disease

2024-11-15

Abstract excerpt

T lymphocytes play a major role in intestinal homeostasis, with a particular impact on the balance between self-renewal and differentiation of intestinal epithelial cells (IECs). In Crohn’s disease (CD) patients, the intestinal mucosa is inflamed, epithelium permeability is increased, and IECs present compositional and functional defects. The role of T lymphocytes interactions with IECs in the physiopathology of C...

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Identifiers and source

Literature Corpus work
554c571e-5150-5d09-be65-107555e8f556
DOI
10.1101/2024.11.12.621219
Open publication

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T cell mediated impairment of epithelial integrity in Crohn’s diseaseDOI 10.1101/2024.11.12.621219
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