Article

Colonic mucosal associated invariant T cells in Crohn’s disease have a diverse and non-public T cell receptor beta chain repertoire

2023-05-07

Abstract excerpt

<h4>Objectives</h4> Mucosal-Associated Invariant T (MAIT) cells are T cells with a semi-invariant T cell receptor (TCR), recognizing riboflavin precursors presented by a non-polymorphic MR1 molecule. As these precursors are produced by the gut microbiome, we characterized the frequency, phenotype and clonality of MAIT cells in human colons with and without Crohn’s disease (CD). <h4>Methods</h4> The transcriptome o...

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Literature Corpus work: 4e4aefc6-9cdd-5e36-8256-b766497cc880
DOI: 10.1101/2023.05.05.23289565

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