Article

Deciphering the cell-intrinsic effect of DNMT3A clonal hematopoiesis in circulating monocytes: potential mechanistic insights into a protective role in Alzheimer’s disease

2023-10-02

Abstract excerpt

<h4>Background</h4> Recent evidence showed an unforeseen connection between clonal hematopoiesis (CH) and protection against Alzheimer’s disease (AD) and found mutant bone marrow-derived cells infiltrate the brain and acquire a microglial-like phenotype, correlating with reduced neuritic plaques and neurofibrillary tangles in non-AD individuals. CH, characterized by somatic mutations in hematopoietic stem cells le...

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Literature Corpus work: 7e39e1ed-b698-5c83-bc41-33b453e10c81
DOI: 10.1101/2023.09.29.23296147

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