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Article

Mutation-resolved single-cell transcriptomics reveals enhanced β-amyloid clearance in TET2-mutant human monocytes.

JCI insight - 24 Aug 2026

Yang Xiao, Fatima Sameen, Sampere-Birlanga Salvador, Ware Akshay, Shumliakivska Mariana, Zanders Lukas, Radhakrishnan Srisurekha, Luxán Guillermo, John David, Günther Stefan, Mas-Peiro Silvia, Dimmeler Stefanie, Zeiher Andreas M, Abplanalp Wesley T

Abstract excerpt

TET2-driven clonal hematopoiesis has been associated with reduced Alzheimer's disease risk, but mechanisms in humans remain unclear. Using mutation-resolved single-cell transcriptomics, we distinguished TET2-mutant and wild-type monocytes within the same aged individuals and identified enrichment of phagocytosis and complement programs in mutant cells. TET2 silencing in human monocytes and macrophages...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42635046
DOI: 10.1172/jci.insight.208804
PMCID: PMC13502165

Genes

TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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