Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clonal Hematopoiesis-Driver DNMT3A Mutations Alter Immune Cells in Heart Failure.

Circulation research - 22 Jan 2021

Abplanalp Wesley Tyler, Cremer Sebastian, John David, Hoffmann Jedrzej, Schuhmacher Bianca, Merten Maximillian, Rieger Michael A, Vasa-Nicotera Mariuca, Zeiher Andreas M, Dimmeler Stefanie

Abstract excerpt

RATIONALE: Clonal hematopoiesis driven by mutations of DNMT3A (DNA methyltransferase 3a) is associated with increased incidence of cardiovascular disease and poor prognosis of patients with chronic heart failure (HF) and aortic stenosis. Although experimental studies suggest that DNMT3A clonal hematopoiesis-driver mutations may enhance inflammation, specific signatures of inflammatory cells in humans are missing....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Methyltransferase 3A
Share to Clonal Hematopoiesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA (Cytosine-5-)-Methyltransferases

Share to Human Umbilical Vein Endothelial Cells

Share to Immunogenetic Phenomena

Share to Paracrine Communication

Share to RNA-Seq

Share to THP-1 Cells

Source

Identifiers

PMID: 33155517
DOI: 10.1161/CIRCRESAHA.120.317104

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clonal Hematopoiesis-Driver DNMT3A Mutations Alter Immune Cells in Heart Failure.PMID 33155517Read ↗

DNMT3A clonal hematopoiesis-driver mutations induce cardiac fibrosis by paracrine activation of fibroblasts.Semantic proximity Read ↗

DNMT3A clonal hematopoiesis-driver mutations induce cardiac fibrosis by paracrine activation of fibroblastsSemantic proximity Read ↗

Cell-intrinsic effects of clonal hematopoiesis in heart failure.Semantic proximity Read ↗

Interaction of inherited genetic variants in the NLRP3 inflammasome/IL-6 pathway with acquired clonal hematopoiesis to modulate mortality risk in patients with HFrEFSemantic proximity Read ↗

Clonal hematopoiesis and cardiovascular disease: deciphering interconnections.Semantic proximity Read ↗

Haematopoietic loss of KDM6A impairs cardiac recovery in heart failure <i>via</i> epigenetic reprogramming of myeloid cellsSemantic proximity Read ↗

A feedback loop: Interactions between Inflammatory Signals and Clonal Hematopoiesis in Cardiovascular Disease.Semantic proximity Read ↗

Genetic modification of inflammation and clonal hematopoiesis-associated cardiovascular riskSemantic proximity Read ↗

Genetic modification of inflammation- and clonal hematopoiesis-associated cardiovascular risk.Semantic proximity Read ↗

Prognostic significance of somatic mutations in myeloid cells of men with chronic heart failure – interaction between loss of Y chromosome and clonal hematopoiesisSemantic proximity Read ↗

Deciphering the cell-intrinsic effect of DNMT3A clonal hematopoiesis in circulating monocytes: potential mechanistic insights into a protective role in Alzheimer’s diseaseSemantic proximity Read ↗

The transcriptome of CMML monocytes is highly inflammatory and reflects leukemia-specific and age-related alterations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.