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Article

Clonal Hematopoiesis in Nonmalignant Disease: Functional Consequences of Mutated Immune Cells by Clonal Hematopoiesis in the Diseased Tissue.

Annual review of pathology - 1 Jan 2026

Koh Youngil, Tengesdal Isak W, Jaiswal Siddhartha

Abstract excerpt

Clonal hematopoiesis, originally identified as a precursor to hematologic malignancies, has emerged as a significant factor in various nonmalignant diseases. Recent research highlights how somatic mutations in hematopoietic stem cells lead to the expansion of circulating mutated immune cells that exert profound effects on organ function and disease progression. These mutated clones display altered inflammatory...

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Source

Identifiers

PMID: 40929507
DOI: 10.1146/annurev-pathmechdis-111523-023442

Genes

ASXL1
DNMT3A
PPM1D
SF3B1
TET2
TP53
U2AF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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