Article

Fatty Acid Transport Protein-2 (FATP2) Inhibition Enhances Glucose Tolerance through α-Cell-mediated GLP-1 Secretion

2025-02-06

Abstract excerpt

<h4>ABSTRACT</h4> Type 2 diabetes affects more than 30 million people in the US, and a major complication is kidney disease. During the analysis of lipotoxicity in diabetic kidney disease, global fatty acid transport protein-2 (FATP2) gene deletion was noted to markedly reduce plasma glucose in db/db mice due to sustained insulin secretion. To identify the mechanism, we observed that islet FATP2 expression was re...

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Literature Corpus work: 7e025602-765c-50af-9795-ef367be26afb
DOI: 10.1101/2025.01.31.635976

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