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Article

Role of glucotoxicity and lipotoxicity in the pathophysiology of Type 2 diabetes mellitus and emerging treatment strategies.

Diabetic medicine : a journal of the British Diabetic Association - 1 Dec 2009

Del Prato S

Abstract excerpt

Type 2 diabetes mellitus is a disease characterized by persistent and progressive deterioration of glucose tolerance. Both insulin resistance and impaired insulin secretion contribute to development of Type 2 diabetes. However, whilst insulin resistance is fully apparent in the pre-diabetic condition, impairment of insulin secretion worsens over the time, being paralleled by a progressive decline in both...

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Identifiers

PMID: 20002468
DOI: 10.1111/j.1464-5491.2009.02847.x

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