Article

β-cell NCK1 is reduced in type 2 diabetes, leading to inefficient β-cell UPR and insulin secretion and revealing sex-specific adaptation during metabolic stress

2026-07-22

Abstract excerpt

<h4>ABSTRACT</h4> Type 2 diabetes is characterized by failure of pancreatic β cells to adapt insulin secretion to metabolic demand, due to impaired β-cell function and/or reduced β-cell mass. The unfolded protein response (UPR) is central to this adaptation by maintaining endoplasmic reticulum homeostasis and supporting insulin biosynthesis, secretion, proliferation, and survival. NCK1, is an adaptor protein that...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b3269cd0-5b6f-502c-82ac-9be5fb8d0337
DOI: 10.64898/2026.07.18.739339

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

β-cell NCK1 is reduced in type 2 diabetes, leading to inefficient β-cell UPR and insulin secretion and revealing sex-specific adaptation during metabolic stressDOI 10.64898/2026.07.18.739339Read

KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein ResponseSemantic proximity Read

Role of the Unfolded Protein Response in<i>β</i>Cell Compensation and Failure during DiabetesSemantic proximity Read

PERK in beta cell biology and insulin biogenesisSemantic proximity Read

Sex differences in islet stress responses support female beta cell resilienceSemantic proximity Read

Sex differences in islet stress responses support female β cell resilienceSemantic proximity Read

Disruption of insulin receptor substrate 2 (Irs2) causes non-obese type 2 diabetes with β-cell dysfunction in the golden (Syrian) hamsterSemantic proximity Read

Separately inherited defects in insulin exocytosis and beta-cell glucose metabolism contribute to type 2 diabetes.Semantic proximity Read

Genetic and biochemical pathways of β‐cell failure in type 2 diabetesSemantic proximity Read

Inside the β Cell: Molecular Stress Response Pathways in Diabetes PathogenesisSemantic proximity Read

Lipid droplets protect human β cells from lipotoxic-induced stress and cell identity changesSemantic proximity Read

An accomplice more than a mere victim: The impact of β-cell ER stress on type 1 diabetes pathogenesisSemantic proximity Read

Pathological β-Cell Endoplasmic Reticulum Stress in Type 2 Diabetes: Current Evidence.Semantic proximity Read