Article

Recovery of human type 2 diabetes beta cell function associates with transcriptomic signatures that point to novel therapeutic targets

2021-09-03

Abstract excerpt

<title>Abstract</title> <p>Remission of type 2 diabetes (T2D) may occur after very low-calorie diets or bariatric surgery, and is associated with improved pancreatic beta cell function. Here, we evaluated if T2D beta cell dysfunction can be rescued ex-vivo and which are the molecular mechanisms involved. Islets from 19 T2D donors were studied after isolation (“basal”) and following culture at 5.5 or 11.1 mmol/l g...

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Literature Corpus work: 002e1594-f003-573c-95c2-e3b94edaef96
DOI: 10.21203/rs.3.rs-871924/v1

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