Article

G6PC2 controls glucagon secretion by defining the setpoint for glucose in pancreatic α-cells

2023-05-24

Abstract excerpt

Impaired glucose suppression of glucagon secretion (GSGS) is a hallmark of type 2 diabetes. A critical role for α-cell intrinsic mechanisms in regulating glucagon secretion was previously established through genetic manipulation of the glycolytic enzyme glucokinase (GCK) in mice. Genetic variation at the G6PC2 locus, encoding an enzyme that opposes GCK, has been reproducibly associated with fasting blood glucose...

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Literature Corpus work: 281b252d-dcbd-5575-b54c-4e4d09848e29
DOI: 10.1101/2023.05.23.541901

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