Article

Design and discovery of a highly potent ultralong-acting GLP-1 and glucagon co-agonist for attenuating renal fibrosis by modulating mitochondrial function

2022-02-02

Abstract excerpt

<title>Abstract</title> <p>GLP-1 receptor (GLP-1R) and glucagon receptor (GCGR) are critical for the maintenance of glucose and energy homeostasis, but their roles in chronic kidney disease (CKD) are still unknown. Herein we found that the expression of GLP-1R and GCGR was lower in kidney from patients with CKD than in control individuals and was correlated with disease severity. RNA-seq analysis showed that aden...

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Literature Corpus work: 385a646a-9cae-519d-b952-ec9f2c2ee82d
DOI: 10.21203/rs.3.rs-1259932/v1

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Design and discovery of a highly potent ultralong-acting GLP-1 and glucagon co-agonist for attenuating renal fibrosis by modulating mitochondrial functionDOI 10.21203/rs.3.rs-1259932/v1Read

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