Article

Disruption of glucagon receptor induces single α-cell hypersecretion through upregulation of VGF

2024-01-26

Abstract excerpt

<title>Abstract</title> <p>Antagonism of the glucagon receptor (GCGR) improves glycemic control both in rodent diabetes models and humans with diabetes. However, GCGR antagonism, as well as GCGR-deficiency in animal models, cause side effects of α-cell hyperplasia and hyperglucagonemia, which limit its clinical applications. The cause of these side effects has been unclear. In this study, we performed single-cell...

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Literature Corpus work: 7de6bbe8-930f-5fb0-939d-bc0234961309
DOI: 10.21203/rs.3.rs-3877444/v1

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