Pathophysiology of type 2 diabetes: targeting islet cell dysfunction.

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Article

Pathophysiology of type 2 diabetes: targeting islet cell dysfunction.

The Journal of the American Osteopathic Association - 1 Mar 2010

Spellman Craig W

Abstract excerpt

Type 2 diabetes mellitus (T2DM) continues to be a major health problem worldwide. It is well known that T2DM is a metabolic disorder characterized by hyperglycemia, which arises from insufficient pancreatic insulin secretion, insulin resistance in peripheral tissues, and inadequate suppression of glucagon production. This suppression results in inadequate uptake, storage, and disposal of ingested glucose...

Topics

Blood Glucose
Diabetes Mellitus, Type 2
Dietary Carbohydrates
Disease Progression
Endocrine Cells
Genetic Predisposition to Disease
Global Health
Glucagon
Glucose
Humans
Incidence
Insulin
Insulin Resistance
Insulin Secretion
Insulin-Secreting Cells
Risk Assessment

Source

Open in PubMed

Identifiers

PMID: 20382838

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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