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Clonal Heterogeneity in Human Pancreatic Ductal Adenocarcinoma and Its Impact on Tumor Progression

2025-02-15

Abstract excerpt

<h4>ABSTRACT</h4> Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer characterized by profound desmoplasia and cellular heterogeneity, which cannot be fully resolved using traditional bulk sequencing approaches. To understand the contribution of this heterogeneity to PDAC biology, we analyzed a large cohort of primary human PDAC samples (n = 62), profiling 443,451 single cells and 53,236 spatial tran...

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Literature Corpus work
7dfb7dc9-5cea-5131-bb5b-32c9bec43140
DOI
10.1101/2025.02.11.637729
Open publication

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Clonal Heterogeneity in Human Pancreatic Ductal Adenocarcinoma and Its Impact on Tumor ProgressionDOI 10.1101/2025.02.11.637729
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