In situ multi-modal characterization of pancreatic cancer reveals tumor cell identity as a defining factor of the surrounding microenvironment.

doi:10.1016/j.celrep.2025.116827

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

In situ multi-modal characterization of pancreatic cancer reveals tumor cell identity as a defining factor of the surrounding microenvironment.

Cell reports - 27 Jan 2026

Lyubetskaya Anna, Rabe Brian, Kavran Andrew, Bai Yulong, Fisher Andrew, Font-Tello Alba, Lewin Anne, Pliner Hannah, Fan Yunfan, Giampapa Lauren, Cheng Yelena, Dai Chao, Hu Ruifeng, Lila Tom, Alloy Alexandre P, Mason Mike, Brett Constance, Brett Todd, Seifuddin Fayaz, Vasquez Grinnell Steven, Stahlschmidt Soren R, Zhao Yilin, Golhar Ryan, Neuhaus Isaac, Carrera Daniel, Rios Carlos, Kar Pradeep, Shukla Abhishek, Bashford-Rogers Rachael, Meyer Matthew J, Abu Shah Enas, Heij Lara, Sivakumar Shivan, Trillo-Tinoco Jimena, Chen Benjamin J, Mavrakis Konstantinos J, Drokhlyansky Eugene

Abstract excerpt

Pancreatic ductal adenocarcinoma is heterogeneous, with low tumor purity, a prominent microenvironment, and complex architecture, which preclude the identification of shared tumor-intrinsic and stromal biology within and across patients. We overcame these challenges by achieving necessary resolution and context through the application of complementary genomics, pathology, and machine-learning approaches to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Pancreatic Ductal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice

Share to Mutation

Share to Pancreatic Neoplasms

Share to Proto-Oncogene Proteins p21(ras)

Share to Single-Cell Analysis

Share to Transcriptome

Share to Tumor Microenvironment

Source

Open in PubMed

Identifiers

PMID: 41533516
DOI: 10.1016/j.celrep.2025.116827

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In situ multi-modal characterization of pancreatic cancer reveals tumor cell identity as a defining factor of the surrounding microenvironment.PMID 41533516Read ↗

Single-cell and spatially resolved atlas of pancreatic cancer reveals immunophenotypes associated with clinical outcomeSemantic proximity Read ↗

Integrating multi-modal transcriptomics identifies cellular subtypes with distinct roles in PDAC progressionSemantic proximity Read ↗

Coordinated single-cell tumor microenvironment dynamics reinforce pancreatic cancer subtypeSemantic proximity Read ↗

Spatially confined sub-tumor microenvironments in pancreatic cancer.Semantic proximity Read ↗

PDAC tumor Immune system escape architecture: Analysis of transcriptomics of mechanisms that TME is tackling immune system in Pancreatic Ductal Adenocarcinoma TumorsSemantic proximity Read ↗

Spatially confined sub-tumor microenvironments orchestrate pancreatic cancer pathobiologySemantic proximity Read ↗

Human Pancreatic Cancer Single-Cell Atlas Reveals Association of CXCL10+ Fibroblasts and Basal Subtype Tumor CellsSemantic proximity Read ↗

High-dimensional deconstruction of pancreatic ductal adenocarcinoma identifies tumor microenvironmental communities associated with survivalSemantic proximity Read ↗

Tumor Microenvironment in Pancreatic Cancer Pathogenesis and Therapeutic ResistanceSemantic proximity Read ↗

Spatial drivers and pre-cancer populations collaborate with the microenvironment in untreated and chemo-resistant pancreatic cancerSemantic proximity Read ↗

Unbiasedly decoding the tumor microenvironment with single-cell multiomics analysis in pancreatic cancerSemantic proximity Read ↗

Integrated spatial proteomics of human PDAC uncovers an expanded tumour-immune-stroma spectrum with genomic associationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.