Article

Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy

2020-08-24

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is projected to be the second leading cause of cancer mortality by 2030. Bulk transcriptomic analyses have distinguished ‘classical’ pancreatic tumors from ‘basal-like’ tumors with more aggressive clinical behaviour. We derived PDAC organoids from primary tumors of 18 patients, together with two matched samples from liver metastases. By single-cell RNA sequencing, we show th...

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Literature Corpus work: ea689b38-99dc-561b-a63f-76a8c927bf1d
DOI: 10.1101/2020.08.23.263160

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