Article

The tumor microenvironment drives transcriptional phenotypes and their plasticity in metastatic pancreatic cancer

2020-08-25

Abstract excerpt

<h4>SUMMARY</h4> Bulk transcriptomic studies have defined classical and basal-like gene expression subtypes in pancreatic ductal adenocarcinoma (PDAC) that correlate with survival and response to chemotherapy; however, the underlying mechanisms that govern these subtypes and their heterogeneity remain elusive. Here, we performed single-cell RNA-sequencing of 23 metastatic PDAC needle biopsies and matched organoid...

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Literature Corpus work: 53aa64fa-25b0-5b08-824a-e5f061eb3caa
DOI: 10.1101/2020.08.25.256214

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