Article

Basal-to-classical phenotypic switch of pancreatic cancer cells upon integration into the duodenal epithelium

2021-02-02

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive solid tumors. Based on transcriptomic classifiers, basal-like and classical PDAC subtypes can be defined that differ in prognosis. Single-cell sequencing has recently revealed that these subtypes coexist in individual tumors. However, the contribution of either clonal heterogeneity or microenvironmental cues to subtype heterogeneity is unclear....

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Literature Corpus work: 33a2885b-b532-59a0-a3e6-8edd3711ea8c
DOI: 10.1101/2021.02.01.429212

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