Article

The polyglutamine amyloid nucleus in living cells is a monomer with competing dimensions of order

2021-08-31

Abstract excerpt

A long-standing goal of the study of amyloids has been to characterize the structural basis of the rate-determining nucleating event. However, the ephemeral nature of that event has made it inaccessible to classical biochemistry, structural biology, and computational approaches. Here, we addressed that limitation by measuring the dependence of amyloid formation on concentration and conformational templates in livi...

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Identifiers and source

Literature Corpus work: 7de08237-7e38-5f8c-bad5-1c878d746cff
DOI: 10.1101/2021.08.29.458132

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