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Article

Structure propensities in mutated polyglutamine peptides.

Interdisciplinary sciences, computational life sciences - 1 Mar 2011

Vanschouwen Bryan M B, Oblinsky Daniel G, Gordon Heather L, Rothstein Stuart M

Abstract excerpt

Polyglutamine is a naturally occurring peptide found within several proteins in neuronal cells of the brain, and its aggregation has been implicated in several neurodegenerative diseases, including Huntington's disease. The resulting aggregates have been demonstrated to possess β-sheet structure, and experimental evidence has demonstrated that aggregation begins with a nucleus composed of a single peptide. In...

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PMID: 21369882
DOI: 10.1007/s12539-011-0058-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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