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Article

Stochastic kinetics of intracellular huntingtin aggregate formation.

Nature chemical biology - 1 Jun 2006

Colby David W, Cassady John P, Lin Grace C, Ingram Vernon M, Wittrup K Dane

Abstract excerpt

Neurodegeneration in Huntington disease is described by neuronal loss in which the probability of cell death remains constant with time. However, the quantitative connection between the kinetics of cell death and the molecular mechanism initiating neurodegeneration remains unclear. One hypothesis...

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Identifiers

PMID: 16699519
DOI: 10.1038/nchembio792

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16699519-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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