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Article

Stochastic kinetics of intracellular huntingtin aggregate formation.

Nature chemical biology - 1 Jun 2006

Colby David W, Cassady John P, Lin Grace C, Ingram Vernon M, Wittrup K Dane

Abstract excerpt

Neurodegeneration in Huntington disease is described by neuronal loss in which the probability of cell death remains constant with time. However, the quantitative connection between the kinetics of cell death and the molecular mechanism initiating neurodegeneration remains unclear. One hypothesis is that nucleation of protein aggregates containing exon I fragments of the mutant huntingtin protein (mhttex1), which...

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Identifiers

PMID: 16699519
DOI: 10.1038/nchembio792

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Stochastic kinetics of intracellular huntingtin aggregate formation.PMID 16699519Read ↗

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