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Article

Polyglutamine expansion mutation yields a pathological epitope linked to nucleation of protein aggregate: determinant of Huntington's disease onset.

PloS one - 25 Jul 2007

Sugaya Keizo, Matsubara Shiro, Kagamihara Yasuhiro, Kawata Akihiro, Hayashi Hideaki

Abstract excerpt

Polyglutamine (polyQ) expansion mutation causes conformational, neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases. These diseases are characterized by the aggregation of misfolded proteins, such as amyloid fibrils, which are toxic to cells. Amyloid fibrils are formed by a n...

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Identifiers

PMID: 17653262
DOI: 10.1371/journal.pone.0000635
PMCID: PMC1914377

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17653262-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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