Article

Theoretical Framework for Prion Aggregation Kinetics: From Nucleation to Spatial Propagation

2026-02-16

Abstract excerpt

<title>Abstract</title> <p>Prion diseases are characterized by the templated conversion of native proteins into misfolded amyloid aggregates exhibiting sigmoidal growth kinetics with distinct lag and growth phases. We present a unified theoretical framework integrating four mathematical models: the Nucleated Polymerization Model (NPM) using moment equations, the Smoluchowski coagulation equation with size-resolve...

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Literature Corpus work: 4d042de1-25ac-516f-bacd-d09ab577838d
DOI: 10.21203/rs.3.rs-8835911/v1

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