Article
Pathologic polyglutamine aggregation begins with a self-poisoning polymer crystal
2023-03-21
Abstract excerpt
A long-standing goal of amyloid research has been to characterize the structural basis of the rate-determining nucleating event. However, the ephemeral nature of nucleation has made this goal unachievable with existing biochemistry, structural biology, and computational approaches. Here, we addressed that limitation for polyglutamine (polyQ), a polypeptide sequence that causes Huntington’s and other amyloid-associ...
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Identifiers and source
- Literature Corpus work
- c8107a8d-1cec-5d7a-bfa4-9e4279379413
- DOI
- 10.1101/2023.03.20.533418