Article

Structural defects in amyloid-β fibrils drive secondary nucleation

2025-04-01

Abstract excerpt

The nucleation of amyloid fibrils from monomeric protein, catalyzed by the surface of existing fibrils, is an important driver of many disorders such as Alzheimer's and Parkinson's diseases. The structural basis of this secondary nucleation process, however, is poorly understood. Here, we ask whether secondary nucleation sites are found predominantly at rare growth defects: defects in the fibril core structure gen...

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Literature Corpus work: e8e664a3-bd23-5c18-84b0-234656f1abc1
DOI: 10.1101/2025.03.31.646415

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