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Article

Polyglutamine aggregation in Huntington and related diseases.

Advances in experimental medicine and biology - 1 Jan 2012

Polling Saskia, Hill Andrew F, Hatters Danny M

Abstract excerpt

Polyglutamine (polyQ)-expansions in different proteins cause nine neurodegenerative diseases. While polyQ aggregation is a key pathological hallmark of these diseases, how aggregation relates to pathogenesis remains contentious. In this chapter, we review what is known about the aggregation process and how cells respond and interact with the polyQ-expanded proteins. We cover detailed biophysical and structural...

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PMID: 23560308
DOI: 10.1007/978-1-4614-5434-2_8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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