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Article

Quantitative connection between polyglutamine aggregation kinetics and neurodegenerative process in patients with Huntington's disease.

Molecular neurodegeneration - 14 May 2012

Sugaya Keizo, Matsubara Shiro

Abstract excerpt

BACKGROUND: Despite enormous progress in elucidating the biophysics of aggregation, no cause-and-effect relationship between protein aggregation and neurodegenerative disease has been unequivocally established. Here, we derived several risk-based stochastic kinetic models that assess genotype/phenotype correlations in patients with Huntington's disease (HD) caused by the expansion of a CAG repeat. Fascinating...

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Identifiers

PMID: 22583646
DOI: 10.1186/1750-1326-7-20
PMCID: PMC3468392

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