Article

Mutant MAPT Induces rDNA Transcriptional Hyperactivation and Nucleolar Stress in Cellular Models

2025-10-05

Abstract excerpt

<title>Abstract</title> <p>Tau is traditionally known for its role in microtubule stabilization, with its pathological aggregation central to tauopathies such as Alzheimer’s disease (AD) and frontotemporal dementia (FTD). Recent evidence suggests that tau also plays important nuclear and nucleolar roles, yet the implications of tau pathology on nucleolar function remain poorly understood. Here, we show that tau l...

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Literature Corpus work: 7dd116a3-0ad9-5fd3-a803-a5961960e061
DOI: 10.21203/rs.3.rs-7713987/v1

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