Article

Nucleolar stress controls mutant Huntingtin toxicity and monitors Huntington’s disease progression

2021-07-10

Abstract excerpt

Transcriptional and cellular stress surveillance deficits are hallmarks of Huntington’s disease (HD), a fatal autosomal dominant neurodegenerative disorder, caused by a pathological expansion of CAG repeats in the Huntingtin ( HTT) gene. The nucleolus, a dynamic nuclear biomolecular condensate and the site of ribosomal RNA (rRNA) transcription, is implicated in the cellular stress response and in protein quality...

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Literature Corpus work: 71ba2c58-ace1-5054-a7f9-993e7a7b4dcc
DOI: 10.1101/2021.07.09.451766

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