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Article

Genetic mutations linked to Parkinson's disease differentially control nucleolar activity in pre-symptomatic mouse models.

Disease models & mechanisms - 1 May 2017

Evsyukov Valentin, Domanskyi Andrii, Bierhoff Holger, Gispert Suzana, Mustafa Rasem, Schlaudraff Falk, Liss Birgit, Parlato Rosanna

Abstract excerpt

Genetic mutations underlying neurodegenerative disorders impair ribosomal DNA (rDNA) transcription suggesting that nucleolar dysfunction could be a novel pathomechanism in polyglutamine diseases and in certain forms of amyotrophic lateral sclerosis/frontotemporal dementia. Here, we investigated nucleolar activity in pre-symptomatic digenic models of Parkinson's disease (PD) that model the multifactorial aetiology...

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Share to Cell Nucleolus
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mice, Knockout

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Share to Protein Deglycase DJ-1

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Source

Open in PubMed Open full text

Identifiers

PMID: 28360124
DOI: 10.1242/dmm.028092
PMCID: PMC5451170

Genes

PINK1
SNCA
PARK7
PTEN
RRN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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