Article

Molecular Mechanism of Nuclear Tau Accumulation and its Role in Protein Synthesis

2020-09-01

Abstract excerpt

Several neurodegenerative diseases present Tau accumulation as the main pathological marker. Tau post-translational modifications such as phosphorylation and acetylation are increased in neurodegenerative patients. Here, we show that Tau hyper-acetylation at residue 174 increases its own nuclear presence and is the result of DNA damage signaling or the lack of SIRT6, both causative of neurodegeneration. Tau-K174ac...

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Identifiers and source

Literature Corpus work: c25f267a-ca30-51e1-93cc-2e08d3bba113
DOI: 10.1101/2020.09.01.276782

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