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Article

Nucleolar dysfunction in Huntington's disease.

Biochimica et biophysica acta - 1 Jun 2014

Lee Junghee, Hwang Yu Jin, Ryu Hyun, Kowall Neil W, Ryu Hoon

Abstract excerpt

Huntington's disease (HD) is a fatal genetic disorder characterized by triad clinical symptoms of chorea, emotional distress, and cognitive decline. Genetic mutation in HD is identified by an expansion of CAG repeats coding for glutamine (Q) in exon 1 of the huntingtin (htt) gene. The exact mechanism on how mutant htt leads to the selective loss of medium spiny neurons (MSNs) in the striatum is still unknown....

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Identifiers

PMID: 24184605
DOI: 10.1016/j.bbadis.2013.09.017
PMCID: PMC3972370

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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