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Article

Knockout of Adamts7 , a Novel Coronary Artery Disease Locus in Humans, Reduces Atherosclerosis in Mice

26 Feb 2015

Abstract excerpt

BACKGROUND: Genome-wide association studies have established ADAMTS7 as a locus for coronary artery disease in humans. However, these studies fail to provide directionality for the association between ADAMTS7 and coronary artery disease. Previous reports have implicated ADAMTS7 in the regulation of vascular smooth muscle cell migration, but a role for and the direction of impact of this gene in atherogenesis have...

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PMID: 25712206
DOI: 10.1161/circulationaha.114.012669

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