A functional polymorphism in ADAMTS7 3'-UTR abrogates miR-654-5p-mediated ADAMTS7 expression suppression and increases the incidence, short-term outcome, and recurrence of large artery atherosclerotic stroke among southern Chinese population.

doi:10.1080/21691401.2026.2670966

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A functional polymorphism in ADAMTS7 3'-UTR abrogates miR-654-5p-mediated ADAMTS7 expression suppression and increases the incidence, short-term outcome, and recurrence of large artery atherosclerotic stroke among southern Chinese population.

Artificial cells, nanomedicine, and biotechnology - 1 Dec 2026

Chen Linfa, Wei Shan, Li Zishan, Zhang Yutian, Li Jiahao, Yan Jinjin, Xiao Chun, Li You

Abstract excerpt

BACKGROUND: A Disintegrin and Metalloproteinase with Thrombospondin motifs 7 (ADAMTS7) plays a critical role in atherosclerosis by degrading the extracellular matrix and modulating smooth muscle cell (SMC) proliferation, migration, and phenotypic transformation. This study investigated the association between the ADAMTS7 single-nucleotide polymorphism (SNP) rs1045130 and large artery atherosclerotic (LAA) stroke....

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PMID: 42184821
DOI: 10.1080/21691401.2026.2670966

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ADAMTS7

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