Article

Cigarette smoking upregulates vascular expression of the novel atherosclerosis risk factor ADAMTS-7

2025-10-29

Abstract excerpt

<h4>Background</h4> Cigarette smoking is an established risk factor for coronary artery disease (CAD) and myocardial infarction. Genetic variants in the extracellular matrix protease ADAMTS-7 were also identified to increase CAD risk. Notably, ADAMTS7 represents the only genomic locus that revealed a gene-environment interaction with smoking. The underlying mechanisms of this interaction remain unclear. <h4>Met...

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Literature Corpus work: 8d1701ce-c0b8-59ad-8029-b9f2dd734d30
DOI: 10.1101/2025.10.28.685237

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