Article

Stronger population suppression by gene drive targeting <i>doublesex</i> from dominant female-sterile resistance alleles

2025-04-20

Abstract excerpt

CRISPR homing drives can be used to suppress a population by targeting female fertility genes. They convert wild-type alleles to drive alleles in the germline of drive heterozygotes by homology-directed repair after DNA cleavage. However, resistance alleles produced by end-joining pose a great threat to homing drive. They prevent further recognition by Cas9, and therefore weaken suppressive power, or even stop sup...

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Literature Corpus work: 7da625fc-a117-5258-9b83-9249c6fe7981
DOI: 10.1101/2025.04.16.649134

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