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Article

Experimental and modeling demonstration of stronger population suppression by gene drive targeting doublesex from dominant female-sterile resistance alleles.

Nature communications - 8 Apr 2026

Chen Weizhe, Wang Ziye, Champer Jackson

Abstract excerpt

CRISPR homing drives can be used to suppress a population by targeting female fertility genes. They convert wild-type alleles to drive alleles in the germline of drive heterozygotes, but resistance alleles can weaken suppressive power, or even stop suppression if they preserve the function of the target gene. We use multiplexed gRNAs targeting doublesex in Drosophila to avoid functional resistance and create...

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PMID: 41951595
DOI: 10.1038/s41467-026-71397-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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