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Article

Population suppression by release of insects carrying a dominant sterile homing gene drive targeting doublesex in Drosophila.

Nature communications - 14 Sept 2024

Chen Weizhe, Guo Jialiang, Liu Yiran, Champer Jackson

Abstract excerpt

CRISPR homing gene drives can suppress pest populations by targeting female fertility genes, converting wild-type alleles into drive alleles in the germline of drive heterozygotes. fsRIDL (female-specific Release of Insects carrying a Dominant Lethal) is a self-limiting population suppression strategy involving continual release of transgenic males carrying female lethal alleles. Here, we propose an improved pest...

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Identifiers

PMID: 39277611
DOI: 10.1038/s41467-024-52473-5
PMCID: PMC11401859

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