Back to search

Article

A spatial multi-omics framework maps meningeal–hippocampal communication and nominates translational targets in Alzheimer’s disease

2026-03-04

Abstract excerpt

<title>Abstract</title> <p>Background Alzheimer's disease (AD) exhibits spatial heterogeneity, yet the mechanisms by which immune-active meninges communicate with vulnerable brain regions during disease progression remain unclear. This study aimed to investigate meninges-hippocampus crosstalk and map the communication patterns during AD pathology development. Methods We employed 5xFAD transgenic mouse models an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
7d588021-6462-5a3b-9a7a-c9acede9b196
DOI
10.21203/rs.3.rs-8920265/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A spatial multi-omics framework maps meningeal–hippocampal communication and nominates translational targets in Alzheimer’s diseaseDOI 10.21203/rs.3.rs-8920265/v1
Multidimensional Transcriptomics Reveals the Pivotal Role of Neuroinflammation in Alzheimer's DiseaseSemantic proximity
Dementia risk genes engage gene networks poised to tune the immune response towards chronic inflammatory statesSemantic proximity
A factor-based analysis of individual human microglia uncovers regulators of an Alzheimer-related transcriptional signatureSemantic proximity
Spatial Transcriptomics of Meningeal Inflammation Reveals Inflammatory Gene Signatures in Adjacent Brain ParenchymaSemantic proximity
Brain high-throughput multi-omics data reveal molecular heterogeneity in Alzheimer’s diseaseSemantic proximity
Spatial Multi-Omics Workflow and Analytical Guidelines for Alzheimer’s NeuropathologySemantic proximity
High-Resolution Spatial Profiling of Microglia Reveals Proximity Associated Immunometabolic Reprogramming in Alzheimer’s DiseaseSemantic proximity
Cell type-resolved proteomics reveals intra- and intercellular signaling in Alzheimer’s diseaseSemantic proximity
Spatial and temporal transcriptomics reveal microglia-astroglia crosstalk in the amyloid-β plaque cell niche of Alzheimer’s diseaseSemantic proximity
A Multi-omic Atlas of Human Choroid Plexus in Alzheimer’s DiseaseSemantic proximity
Tau Pathology Drives Dementia Risk-Associated Gene Networks toward Chronic Inflammatory States and Immunosuppression.Semantic proximity
Super-resolved spatial transcriptomics reveals early hippocampal RNA localization changes in a mouse model of Alzheimer’s diseaseSemantic proximity
Select a neighboring publication to make it the new centre.