Article
Identification of novel prostate cancer drivers using RegNetDriver: a framework for integration of genetic and epigenetic alterations with tissue-specific regulatory network.
Genome biology - 27 Jul 2017
Dhingra Priyanka, Martinez-Fundichely Alexander, Berger Adeline, Huang Franklin W, Forbes Andre Neil, Liu Eric Minwei, Liu Deli, Sboner Andrea, Tamayo Pablo, Rickman David S, Rubin Mark A, Khurana Ekta
Abstract excerpt
We report a novel computational method, RegNetDriver, to identify tumorigenic drivers using the combined effects of coding and non-coding single nucleotide variants, structural variants, and DNA methylation changes in the DNase I hypersensitivity based regulatory network. Integration of multi-omics data from 521 prostate tumor samples indicated a stronger regulatory impact of structural variants, as they affect...
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