Article
Chromatin interactions and candidate genes at ten prostate cancer risk loci.
Scientific reports - 16 Mar 2016
Du Meijun, Tillmans Lori, Gao Jianzhong, Gao Ping, Yuan Tiezheng, Dittmar Rachel L, Song Wei, Yang Yuehong, Sahr Natasha, Wang Tao, Wei Gong-Hong, Thibodeau Stephen N, Wang Liang
Abstract excerpt
Genome-wide association studies have identified more than 100 common single nucleotide polymorphisms (SNPs) that are associated with prostate cancer risk. However, the vast majority of these SNPs lie in noncoding regions of the genome. To test whether these risk SNPs regulate their target genes through long-range chromatin interactions, we applied capture-based 3C sequencing technology to investigate possible...
Topics
Join the communities discussing this publication.