Article
Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans.
Human molecular genetics - 1 Oct 2015
Amin Al Olama Ali, Dadaev Tokhir, Hazelett Dennis J, Li Qiuyan, Leongamornlert Daniel, Saunders Edward J, Stephens Sarah, Cieza-Borrella Clara, Whitmore Ian, Benlloch Garcia Sara, Giles Graham G, Southey Melissa C, Fitzgerald Liesel, Gronberg Henrik, Wiklund Fredrik, Aly Markus, Henderson Brian E, Schumacher Fredrick, Haiman Christopher A, Schleutker Johanna, Wahlfors Tiina, Tammela Teuvo L, Nordestgaard Børge G, Key Tim J, Travis Ruth C, Neal David E, Donovan Jenny L, Hamdy Freddie C, Pharoah Paul, Pashayan Nora, Khaw Kay-Tee, Stanford Janet L, Thibodeau Stephen N, Mcdonnell Shannon K, Schaid Daniel J, Maier Christiane, Vogel Walther, Luedeke Manuel, Herkommer Kathleen, Kibel Adam S, Cybulski Cezary, Wokołorczyk Dominika, Kluzniak Wojciech, Cannon-Albright Lisa, Brenner Hermann, Butterbach Katja, Arndt Volker, Park Jong Y, Sellers Thomas, Lin Hui-Yi, Slavov Chavdar, Kaneva Radka, Mitev Vanio, Batra Jyotsna, Clements Judith A, Spurdle Amanda, Teixeira Manuel R, Paulo Paula, Maia Sofia, Pandha Hardev, Michael Agnieszka, Kierzek Andrzej, Govindasami Koveela, Guy Michelle, Lophatonanon Artitaya, Muir Kenneth, Viñuela Ana, Brown Andrew A, Freedman Mathew, Conti David V, Easton Douglas, Coetzee Gerhard A, Eeles Rosalind A, Kote-Jarai Zsofia
Abstract excerpt
Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly...
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