Article

An age-specific platelet differentiation path from hematopoietic stem cells contributes to exacerbated thrombosis

2024-02-24

Abstract excerpt

<h4>SUMMARY</h4> Platelet dysregulation is drastically increased with advanced age and contributes to making cardiovascular disorders the leading cause of death of elderly humans. Hematopoietic stem and progenitor cells continuously give rise to platelets, but their contributions to variable platelet production and activity throughout life remain unclear. Here we reveal a direct differentiation pathway from hemat...

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Literature Corpus work: 7d5120dc-8421-5736-bad7-01b0c7c218c7
DOI: 10.1101/2024.02.23.581812

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