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Hematopoietic stem cell heterogeneity and age-associated platelet bias are evolutionarily conserved

23 Aug 2024

Abstract excerpt

Hematopoietic stem cells (HSCs) reconstitute multilineage human hematopoiesis after clinical bone marrow (BM) transplantation and are the cells of origin of some hematological malignancies. Although HSCs provide multilineage engraftment, individual murine HSCs are lineage biased and contribute unequally to blood cell lineages. Here, we performed high-throughput single-cell RNA sequencing in mice after xenograft...

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PMID: 39178276
DOI: 10.1126/sciimmunol.adk3469

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