Article

Platelet Factor 4 (PF4) Regulates Hematopoietic Stem Cell Aging

2024-11-27

Abstract excerpt

Hematopoietic stem cells (HSCs) responsible for blood cell production and their bone marrow regulatory niches undergo age-related changes, impacting immune responses and predisposing individuals to hematologic malignancies. Here, we show that the age-related alterations of the megakaryocytic niche and associated downregulation of Platelet Factor 4 (PF4) are pivotal mechanisms driving HSC aging. PF4-deficient mice...

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Identifiers and source

Literature Corpus work: 07ec8522-cf7a-581c-963a-b14327b11a63
DOI: 10.1101/2024.11.25.625252

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