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Article

Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells.

Nature communications - 24 Mar 2016

Grover Amit, Sanjuan-Pla Alejandra, Thongjuea Supat, Carrelha Joana, Giustacchini Alice, Gambardella Adriana, Macaulay Iain, Mancini Elena, Luis Tiago C, Mead Adam, Jacobsen Sten Eirik W, Nerlov Claus

Abstract excerpt

Aged haematopoietic stem cells (HSCs) generate more myeloid cells and fewer lymphoid cells compared with young HSCs, contributing to decreased adaptive immunity in aged individuals. However, it is not known how intrinsic changes to HSCs and shifts in the balance between biased HSC subsets each contribute to the altered lineage output. Here, by analysing HSC transcriptomes and HSC function at the single-cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27009448
DOI: 10.1038/ncomms11075
PMCID: PMC4820843

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